11 research outputs found

    Idea to Invention Project Report

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    The United States Patent and Trademark Office (USPTO) estimates that 1-3% of patented inventions produce profits for the inventor. The cost of filing and examination for a non-provisional patent can range from 2,000to2,000 to 10,000 and beyond. ATC Company understands this uncertainty and will undertake a project to invent a new shelter product and determine its marketability, prior to investing in a non-provisional patent. The Idea to Invention project objective is to apply Project Management principles and develop a process for inventing an idea, measuring the idea’s utility and commercial viability as a product, conducting a patent search and producing a thorough Provisional Patent Application. Specifically, the project will deliver both a product line of ATC’s and a process for establishing first to invent rights to patenting the ATC’s function and method of operation. Unlike most recreational tent products available, ATCs do not require a flat or suitable site for setup; rather, ATCs deliver ultralightweight, highly adaptable weather protection and concealment nearly anywhere in the field.Abstract / Literature Review Results / Project Management Approach / Market Identification and Business Need / Scope Management from Idea to Invention / Product Scope Definition / Research, Development, Conditions Use Testing / Active Risk and Opportunity Management / Quality Management in Delivering a Marketable Product / PM Based Patent Search Processes and Strategy / Invention Assessment for All Terrain Cover Concept / Conclusion and Recommendations / Lessons Learned / References / Appendix A, ATC Drawings / Appendix B, Provisional Patent Application (PPA

    LSD increases primary process thinking via serotonin 2A receptor activation

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    Rationale: Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previously been shown to increase primary process thinking - an ontologically and evolutionary early, implicit, associative, and automatic mode of thinking which is typically occurring during altered states of consciousness such as dreaming. However, it is still largely unknown whether LSD induces primary process thinking under placebo-controlled, standardized experimental conditions and whether these effects are related to subjective experience and 5-HT2A receptor activation. Therefore, this study aimed to test the hypotheses that LSD increases primary process thinking and that primary process thinking depends on 5-HT2A receptor activation and is related to subjective drug effects. Methods: Twenty-five healthy subjects performed an audio-recorded mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally) and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally). The main outcome variable in this study was primary index (PI), a formal measure of primary process thinking in the imagery reports. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC) rating scale. Results: LSD, compared with placebo, significantly increased primary index (p < 0.001, Bonferroni-corrected). The LSD-induced increase in primary index was positively correlated with LSD-induced disembodiment (p < 0.05, Bonferroni-corrected), and blissful state (p < 0.05, Bonferroni-corrected) on the 5D-ASC. Both LSD-induced increases in primary index and changes in state of consciousness were fully blocked by ketanserin. Conclusion: LSD induces primary process thinking via activation of 5-HT2A receptors and in relation to disembodiment and blissful state. Primary process thinking appears to crucially organize inner experiences during both dreams and psychedelic states of consciousness

    Stem cell-based bone and dental regeneration: a view of microenvironmental modulation

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